Associated Factors of Drug Resistance among Tuberculosis Patients at Kafue District Hospital

Abstract

Drug resistance in tuberculosis (TB) poses a significant public health challenge worldwide. This dissertation investigates the associated factors contributing to drug resistance among TB patients, shedding light on critical aspects of TB management and control. The study employed a mixed methods approach, including retrospective patient record analysis and qualitative interviews. The analysis of patient records revealed a concerning rise in drug resistance rates, particularly at Kafue District Hospital. Factors associated with drug resistance included inadequate treatment adherence, previous TB treatment history, and comorbidities such as HIV infection. Qualitative interviews with TB patients and healthcare providers provided valuable insights into the social and healthcare-related determinants of drug resistance. Stigmatization, economic constraints, and limited access to quality healthcare services emerged as significant challenges faced by TB patients. This dissertation underscores the multifaceted nature of drug resistance among TB patients. It highlights the urgent need for tailored interventions, improved treatment adherence support, and enhanced access to comprehensive healthcare services. Addressing these factors is crucial to mitigating the growing threat of drug-resistant TB and advancing global efforts toward TB control and elimination.